logo
ResearchBunny Logo
Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

Medicine and Health

Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

S. Chiba, S. J. Frey, et al.

This groundbreaking research by Shiho Chiba and colleagues engineered innovative nanoparticles that successfully induce robust immunity against SARS-CoV-2, showcasing an effective one-shot vaccine approach that completely protects against infection. With no viral presence in the lungs of test subjects, this study paves the way for potential applications against numerous pathogens.

00:00
00:00
Playback language: English
Abstract
The COVID-19 pandemic necessitates effective vaccines. This study engineered nanoparticles displaying multiple copies of the SARS-CoV-2 spike (S) protein. These nanoparticles, used as a vaccine, generated high neutralizing antibody titers and protected Syrian hamsters from SARS-CoV-2 challenge after a single immunization, with no infectious virus detected in the lungs. This platform offers potential for broad application against SARS-CoV-2 and future pathogens.
Publisher
Communications Biology
Published On
May 19, 2021
Authors
Shiho Chiba, Steven J. Frey, Peter J. Halfmann, Makoto Kuroda, Tadashi Maemura, Jie E. Yang, Elizabeth R. Wright, Yoshihiro Kawaoka, Ravi S. Kane
Tags
COVID-19
SARS-CoV-2
vaccines
nanoparticles
neutralizing antibodies
immunization

Related Publications

Explore these studies to deepen your understanding of the subject.

Updated Insights into the T Cell-Mediated Immune Response against SARS-CoV-2: A Step towards Efficient and Reliable Vaccines
Biology

Updated Insights into the T Cell-Mediated Immune Response against SARS-CoV-2: A Step towards Efficient and Reliable Vaccines

E. Michal, S. L. Cosby, et al.

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
Medicine and Health

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

J. Logue, R. M. Johnson, et al.

A single dose of recombinant VSV-ΔG-spike vaccine provides protection against SARS-CoV-2 challenge
Medicine and Health

A single dose of recombinant VSV-ΔG-spike vaccine provides protection against SARS-CoV-2 challenge

Y. Yahalom-ronen, H. Tamir, et al.

Humoral and T Cell Immune Responses against SARS-CoV-2 after Primary and Homologous or Heterologous Booster Vaccinations and Breakthrough Infection: A Longitudinal Cohort Study in Malaysia
Biology

Humoral and T Cell Immune Responses against SARS-CoV-2 after Primary and Homologous or Heterologous Booster Vaccinations and Breakthrough Infection: A Longitudinal Cohort Study in Malaysia

J. Y. L. Fu, M. H. Pukhari, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny