This study investigated the relationship between multi-omics signatures (gut microbiome, fecal and serum metabolome) and metabolic response to dietary inulin in individuals with new-onset pre/diabetes. The study comprised a cross-sectional case-control study comparing lean, obese, and diabetic individuals, followed by an interventional trial where individuals with diabetes received inulin supplementation for three months. Results showed distinct multi-omics patterns associated with obesity and diabetes. Inulin supplementation improved glycemic indices, with the response influenced by baseline glycemic status and specific microbial signatures. These findings suggest the potential for personalized nutritional interventions based on baseline multi-omics profiles.

N. Ďásková, I. Modos, M. Krbcová, M. Kuzma, H. Pelantová, J. Hradecký, M. Heczková, M. Bratová, P. Videňská, P. Šplíchalová, M. Králová, M. Heniková, J. Potočková, A. Ouřadová, R. Landberg, T. Kühn, M. Cahová, J. Gojda