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Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment

Medicine and Health

Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment

A. H. C. Anthis, M. P. Abundo, et al.

This innovative study introduces a modular intelligent suture support sealant patch that revolutionizes early leak detection and containment in gastrointestinal surgery. Conducted by a team including Alexandre H. C. Anthis and Maria Paulene Abundo, this patch provides reliable leak detection within a mere 15 minutes in gastric scenarios and within 3 hours in intestinal cases.

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Playback language: English
Abstract
Millions of patients undergo gastrointestinal surgery annually, with anastomotic leaks occurring in around 10% of cases. Current detection methods lack sensitivity and specificity. This study presents a modular, intelligent suture support sealant patch for early leak detection and containment. pH and/or enzyme-responsive sensing elements are detectable via point-of-need ultrasound. The patch reliably detects leaks within 3 hours in intestinal and 15 minutes in gastric scenarios, paving the way for next-generation suture support materials.
Publisher
Nature Communications
Published On
Nov 27, 2022
Authors
Alexandre H. C. Anthis, Maria Paulene Abundo, Anna L. Neuer, Elena Tsolaki, Jachym Rosendorf, Thomas Rduch, Fabian H. L. Starsich, Bernhard Weisse, Vaclav Liska, Andrea A. Schlegel, Mikhail G. Shapiro, Inge K. Herrmann
Tags
gastrointestinal surgery
anastomotic leaks
early leak detection
suture support sealant
intelligent patch
ultrasound sensing

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