Medicine and Health

Microbiota-gut-brain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets

C. Chen, G. Wang, et al.

This review synthesizes evidence that the microbiota‑gut‑brain axis modulates neuroinflammation, blood‑brain barrier integrity, protein misfolding, and neuronal homeostasis via microbial metabolites such as short‑chain fatty acids, tryptophan derivatives, and bile acids, and explores microbiota‑targeted therapies. Research was conducted by Ce Chen, Guo-qing Wang, Dai-di Li, and Feng Zhang.... show more

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