Medicine and Health

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

N. L. Mason, K. P. C. Kuypers, et al.

Discover groundbreaking research by N. L. Mason and colleagues exploring how psilocybin affects glutamate levels in the brain and its fascinating ties to ego dissolution. This study reveals intriguing region-dependent changes in glutamate that may illuminate psilocybin's therapeutic potential.

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Index

Abstract

This study investigated the effects of psilocybin on glutamate levels in the brain and their correlation with ego dissolution. Using a double-blind, placebo-controlled design and ultra-high field multimodal brain imaging, researchers found that psilocybin induced region-dependent alterations in glutamate. Higher medial prefrontal cortical glutamate was associated with negatively experienced ego dissolution, while lower hippocampal glutamate was linked to positively experienced ego dissolution. These findings offer insights into the neurobiological mechanisms of psilocybin and may provide a neurochemical basis for its therapeutic effects.

Publisher

Neuropsychopharmacology

Published On

Oct 26, 2020

Authors

N. L. Mason, K. P. C. Kuypers, F. Müller, J. Reckweg, D. H. Y. Tse, S. W. Toennies, N. R. P. W. Hutten, J. F. A. Jansen, P. Stiers, A. Feiding, J. G. Ramaekers

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