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Abstract
This paper develops and analyzes an epidemiological compartmental model using multi-objective genetic algorithm design optimization to compare COVID-19 intervention scenarios in São Paulo, Brazil. The study examines the impact of strategy type, social distancing extent, time window, and personal protection levels on transmission dynamics. Results suggest a stepping-down reduction in social distancing every 80 days as the optimal strategy, contingent upon a 5–10% increase in adherence to protective guidelines.
Publisher
Nature Communications
Published On
Jan 18, 2021
Authors
Osmar Pinto Neto, Deanna M. Kennedy, José Clark Reis, Yiyu Wang, Ana Carolina Brisola Brizzi, Gustavo José Zambrano, Joabe Marcos de Souza, Wellington Pedroso, Rodrigo Cunha de Mello Pedreiro, Bruno de Matos Brizzi, Ellysson Oliveira Abinader, Renato Amaro Zângaro
Tags
COVID-19
epidemiological model
genetic algorithm
social distancing
transmission dynamics
Brazil
intervention strategies

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