Engineering and Technology

Machine learning enables design automation of microfluidic flow-focusing droplet generation

A. Lashkaripour, C. Rodriguez, et al.

Explore the innovative DAFD tool developed by researchers including Ali Lashkaripour and Christopher Rodriguez. This web-based solution leverages machine learning to enhance droplet-based microfluidic devices, ensuring precision in droplet generation essential for life sciences applications.

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Abstract

Droplet-based microfluidic devices offer cost-effective screening platforms for life science applications. However, the unpredictable nature of droplet generation hinders efficient device engineering. This paper introduces DAFD, a web-based tool using machine learning to predict and automate the design of flow-focusing droplet generators. DAFD predicts droplet diameter and rate with high accuracy (MAE < 10 µm and 20 Hz), delivering user-specified performance within a narrow margin. The tool's design allows community extension to support additional fluid combinations, simplifying microfluidics adoption in life sciences.

Publisher

Nature Communications

Published On

Jan 04, 2021

Authors

Ali Lashkaripour, Christopher Rodriguez, Noushin Mehdipour, Rizki Mardian, David McIntyre, Luis Ortiz, Joshua Campbell, Douglas Densmore

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