Medicine and Health

Lisocabtagene maraleucel in follicular lymphoma: the phase 2 TRANSCEND FL study

F. Morschhauser, S. Dahiya, et al.

This groundbreaking phase 2 TRANSCEND FL study showcases the remarkable efficacy and safety of lisocabtagene maraleucel (liso-cel) in treating relapsed/refractory follicular lymphoma. With promising overall response and complete response rates noted among high-risk patients, this research conducted by a talented group of authors speaks volumes about advancements in lymphoma therapies.

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Abstract

This phase 2 TRANSCEND FL study evaluated lisocabtagene maraleucel (liso-cel) in relapsed/refractory (R/R) follicular lymphoma (FL), including patients with high-risk features. Primary/key secondary endpoints were overall response rate (ORR)/complete response (CR) rate. In 130 patients (median follow-up, 18.9 months), primary/key secondary endpoints were met. High ORR and CR rates were observed in both third-line or later and second-line FL. Cytokine release syndrome and neurological events were observed, but mostly low grade. Liso-cel demonstrated efficacy and safety in R/R FL, including high-risk second-line FL.

Publisher

Nature Medicine

Published On

Jun 03, 2024

Authors

Franck Morschhauser, Saurabh Dahiya, M. Lia Palomba, Alejandro Martín García-Sancho, Juan Luis Reguera Ortega, John Kuruvilla, Ulrich Jäger, Guillaume Cartron, Koji Izutsu, Martin Dreyling, Brad Kahl, Hervé Ghesquières, Kirit Ardeshna, Hideki Goto, Anna Maria Barbui, Jeremy S. Abramson, Peter Borchmann, Isabelle Fleury, Stephan Mielke, Alan Skarbnik, Sven de Vos, Manali Kamdar, Reem Karmali, Andreas Viardot, Thalia Farazi, Omotayo Fasan, James Lymp, Min Vedal, Rina Nishii, Ariel Avilion, Jessica Papuga, Jinender Kumar, Loretta J. Nastoupil

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