Medicine and Health

Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis

N. Zerrouk, R. Alcraft, et al.

This exciting study conducted by Naouel Zerrouk, Rachel Alcraft, Benjamin A. Hall, Franck Augé, and Anna Niarakis reveals a groundbreaking computational framework that models M1 and M2 macrophage behavior in rheumatoid arthritis. By identifying key therapeutic targets, it offers hope for innovative treatments to combat this debilitating disease.

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Abstract

Macrophages play a crucial role in rheumatoid arthritis (RA), with M1 macrophages promoting inflammation and M2 macrophages resolving it. This study developed a computational framework to model M1 and M2 macrophage behavior in RA using Boolean models inferred from molecular interaction maps. The framework, utilizing the CaSQ and BMA tools on a high-performance computing cluster, identified potential therapeutic targets: NFkB, JAK1/JAK2, and ERK1/Notch1 for selectively suppressing M1 macrophages, and GSK3B for promoting M2 macrophages.

Publisher

npj Systems Biology and Applications

Published On

Jan 26, 2024

Authors

Naouel Zerrouk, Rachel Alcraft, Benjamin A. Hall, Franck Augé, Anna Niarakis

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