This study investigates the extent to which language dominance, typically left-hemispheric, is reflected in the broader functional architecture of the cortex. Using data from the Human Connectome Project, the researchers found that atypical language dominance (right-hemispheric) is associated with global shifts in cortical organization, specifically in the macroscale functional gradients that organize cortical networks. Both language lateralization and gradient asymmetries showed a partial genetic basis. These findings link individual variability in hemispheric specialization with global cortical organization.

Loïc Labache, Tian Ge, B. T. Thomas Yeo, Avram J. Holmes