Medicine and Health

Lactiplantibacillus plantarum P9 for chronic diarrhea in young adults: a large double-blind, randomized, placebo-controlled trial

N. Yang, T. Ma, et al.

This randomized, double-blind, placebo-controlled trial explored the effects of *Lactiplantibacillus plantarum* P9 in young adults experiencing chronic diarrhea. The study found a significant reduction in diarrhea severity following a 28-day intervention, suggesting promise for probiotics in this condition. Conducted by a team of dedicated researchers, the findings open new avenues for managing chronic diarrhea.

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Abstract

This randomized, double-blind, placebo-controlled trial (ChiCTR2000038410) evaluated the effects of *Lactiplantibacillus plantarum* P9 (P9) in young adults with chronic diarrhea. A 28-day intervention followed by a 14-day post-intervention period showed a modest but statistically significant reduction in diarrhea severity in both intention-to-treat and per-protocol analyses compared to placebo. The study highlights the potential of probiotics in managing chronic diarrhea but notes limitations including the lack of blood parameter assessment and short intervention period.

Publisher

Nature Communications

Published On

Aug 09, 2024

Authors

Ni Yang, Teng Ma, Yong Xie, Qiong Li, Yingmeng Li, Longjin Zheng, Yalin Li, Qiuping Xiao, Zhihong Sun, Kexuan Zuo, Lai-Yu Kwok, Nonghua Lu, Wenjun Liu, Heping Zhang

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