Positron emission particle tracking (PEPT) enables 3D localization and tracking of single positron-emitting radiolabelled particles with high spatiotemporal resolution. The translation of PEPT to the biomedical imaging field has been limited due to challenges in radiolabeling biocompatible particles with sufficient specific activity and isolating single particles in the sub-micrometre size range. This study reports the synthesis and ⁶⁸Ga-radiolabeling of homogeneous 950 nm silica particles with high specific activities (2.1 ± 1.4 kBq per particle), and the isolation and manipulation of a single particle. In vivo PEPT and dynamic positron emission tomography (PET) imaging of a single radiolabeled sub-micrometre particle were performed using a pre-clinical PET/CT scanner. This work opens possibilities for real-time, whole-body quantitative assessment of hemodynamics using minimal radioactive dose.
Publisher
Nature Nanotechnology
Published On
Jan 19, 2024
Authors
Juan Pellico, Laurence Vass, Amaia Carrascal-Miniño, Francis Man, Jana Kim, Kavitha Sunassee, David Parker, Philip J. Blower, Paul K. Marsden, Rafael T. M. de Rosales
Tags
Positron emission particle tracking
radiolabeling
biocompatible particles
in vivo imaging
hemodynamics
PET imaging
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