Medicine and Health

In vivo real-time positron emission particle tracking (PEPT) and single particle PET

J. Pellico, L. Vass, et al.

Discover how a team of researchers, including Juan Pellico and Laurence Vass, has pioneered the 3D tracking of single positron-emitting particles, overcoming significant challenges in biocompatibility and radiolabeling. This breakthrough could lead to real-time, whole-body assessments of hemodynamics using minimal radioactive doses.

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~3 min • Beginner • English

Index

Abstract

Positron emission particle tracking (PEPT) enables 3D localization and tracking of single positron-emitting radiolabelled particles with high spatiotemporal resolution. The translation of PEPT to the biomedical imaging field has been limited due to the lack of methods to radiolabel biocompatible particles with sufficient specific activity and protocols to isolate a single particle in the sub-micrometre size range, below the threshold for capillary embolization. Here we report two key developments: the synthesis and 68Ga-radiolabelling of homogeneous silica particles of 950 nm diameter with unprecedented specific activities (2.1 ± 1.4 kBq per particle), and the isolation and manipulation of a single particle. We have combined these developments to perform in vivo PEPT and dynamic positron emission tomography (PET) imaging of a single radiolabelled sub-micrometre size particle using a pre-clinical positron emission tomography/computed tomography scanner. This work opens possibilities for quantitative assessment of haemodynamics in vivo in real time, at the whole-body level using minimal amounts of injected radioactive dose and material.

Publisher

Nature Nanotechnology

Published On

Jan 19, 2024

Authors

Juan Pellico, Laurence Vass, Amaia Carrascal-Miniño, Francis Man, Jana Kim, Kavitha Sunassee, David Parker, Philip J. Blower, Paul K. Marsden, Rafael T. M. de Rosales

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