Medicine and Health

In vivo real-time positron emission particle tracking (PEPT) and single particle PET

J. Pellico, L. Vass, et al.

Discover how a team of researchers, including Juan Pellico and Laurence Vass, has pioneered the 3D tracking of single positron-emitting particles, overcoming significant challenges in biocompatibility and radiolabeling. This breakthrough could lead to real-time, whole-body assessments of hemodynamics using minimal radioactive doses.

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Abstract

Positron emission particle tracking (PEPT) enables 3D localization and tracking of single positron-emitting radiolabelled particles with high spatiotemporal resolution. The translation of PEPT to the biomedical imaging field has been limited due to challenges in radiolabeling biocompatible particles with sufficient specific activity and isolating single particles in the sub-micrometre size range. This study reports the synthesis and ⁶⁸Ga-radiolabeling of homogeneous 950 nm silica particles with high specific activities (2.1 ± 1.4 kBq per particle), and the isolation and manipulation of a single particle. In vivo PEPT and dynamic positron emission tomography (PET) imaging of a single radiolabeled sub-micrometre particle were performed using a pre-clinical PET/CT scanner. This work opens possibilities for real-time, whole-body quantitative assessment of hemodynamics using minimal radioactive dose.

Publisher

Nature Nanotechnology

Published On

Jan 19, 2024

Authors

Juan Pellico, Laurence Vass, Amaia Carrascal-Miniño, Francis Man, Jana Kim, Kavitha Sunassee, David Parker, Philip J. Blower, Paul K. Marsden, Rafael T. M. de Rosales

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