Medicine and Health

Impact of enzalutamide on patient-reported fatigue in patients with prostate cancer: data from the pivotal clinical trials

B. F. Tombal, S. J. Freedland, et al.

Dive into groundbreaking research led by Bertrand F. Tombal and colleagues exploring how enzalutamide impacts fatigue among prostate cancer patients. This study uncovers initial fatigue spikes before a potential stabilization, shedding light on critical clinical management aspects in treatment.

00:00

Playback language: English

Index

Abstract

This study investigates the effect of enzalutamide on patient-reported fatigue in prostate cancer patients using data from four pivotal, placebo-controlled trials (ARCHES, PROSPER, PREVAIL, and AFFIRM). Fatigue was assessed using the FACT-P GP1 item. Results showed an initial increase in fatigue in both enzalutamide and placebo groups within the first 13-17 weeks, with subsequent stabilization or improvement. Worsening of fatigue was more common with enzalutamide plus ADT in three of the four trials, except AFFIRM, which included a more symptomatic population. The findings highlight the need for clinical management of fatigue, especially early in treatment.

Publisher

Prostate Cancer and Prostatic Diseases

Published On

Sep 13, 2021

Authors

Bertrand F. Tombal, Stephen J. Freedland, Andrew J. Armstrong, Tomasz M. Beer, Arnulf Stenzl, Cora N. Sternberg, Maha Hussain, Arijit Ganguly, Krishnan Ramaswamy, Hemant Bhadauria, Cristina Ivanescu, James Turnbull, Stefan Holmström, Fred Saad

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial

H. Eslahi, M. Shakiba, et al.

Medicine and Health

Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study

D. Junker, M. Wu, et al.

Medicine and Health

The prognostic role of diet quality in patients with MAFLD and physical activity: data from NHANES

J. Huang, Y. Wu, et al.

Medicine and Health

Health-related quality of life, psychological distress, and fatigue in metastatic castration-resistant prostate cancer patients treated with radium-223 therapy

M. J. V. D. Doelen, I. M. Oving, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny