Medicine and Health

Impact of enzalutamide on patient-reported fatigue in patients with prostate cancer: data from the pivotal clinical trials

B. F. Tombal, S. J. Freedland, et al.

Dive into groundbreaking research led by Bertrand F. Tombal and colleagues exploring how enzalutamide impacts fatigue among prostate cancer patients. This study uncovers initial fatigue spikes before a potential stabilization, shedding light on critical clinical management aspects in treatment.

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Abstract

This study investigates the effect of enzalutamide on patient-reported fatigue in prostate cancer patients using data from four pivotal, placebo-controlled trials (ARCHES, PROSPER, PREVAIL, and AFFIRM). Fatigue was assessed using the FACT-P GP1 item. Results showed an initial increase in fatigue in both enzalutamide and placebo groups within the first 13-17 weeks, with subsequent stabilization or improvement. Worsening of fatigue was more common with enzalutamide plus ADT in three of the four trials, except AFFIRM, which included a more symptomatic population. The findings highlight the need for clinical management of fatigue, especially early in treatment.

Publisher

Prostate Cancer and Prostatic Diseases

Published On

Sep 13, 2021

Authors

Bertrand F. Tombal, Stephen J. Freedland, Andrew J. Armstrong, Tomasz M. Beer, Arnulf Stenzl, Cora N. Sternberg, Maha Hussain, Arijit Ganguly, Krishnan Ramaswamy, Hemant Bhadauria, Cristina Ivanescu, James Turnbull, Stefan Holmström, Fred Saad

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