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Abstract
This study investigates the genetic architecture of the language network's functional connectivity using resting-state imaging data from 29,681 UK Biobank participants. Multivariate genome-wide association analysis identified 14 genomic loci associated with network connectivity, three of which were also linked to intrahemispheric connectivity asymmetry. Polygenic scores revealed that lower language abilities, dyslexia, and left-handedness were associated with reduced leftward asymmetry. Exome-wide analysis suggested seven additional genes. These findings highlight genetic contributions to language network organization and related behavioral traits.
Publisher
Communications Biology
Published On
Sep 28, 2024
Authors
Jitse S. Amelink, Merel C. Postema, Xiang-Zhen Kong, Dick Schijven, Amaia Carrión-Castillo, Sourena Soheili-Nezhad, Zhiqiang Sha, Barbara Molz, Marc Joliot, Simon E. Fisher, Clyde Francks
Tags
genetic architecture
language network
functional connectivity
dyslexia
asymmetry
biobank
genomic loci

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