Biologynpj Systems Biology and Applications
Identifying the essential nutritional requirements of the probiotic bacteria *Bifidobacterium animalis* and *Bifidobacterium longum* through genome-scale modeling
M. Schöpping, P. Gaspar, et al.
This enlightening research by Marie Schöpping, Paula Gaspar, Ana Rute Neves, Carl Johan Franzén, and Ahmad A. Zeidan unveils strain-specific genome-scale metabolic models for *Bifidobacterium animalis* subsp. *lactis* BB-12 and *B. longum* subsp. *longum* BB-46. The study reveals vital nutritional requirements and demonstrates that a chemically defined medium can support comparable growth to complex media, showcasing innovative model predictions that were validated experimentally.
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