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Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma

Medicine and Health

Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma

J. Ge, Y. Meng, et al.

Discover groundbreaking insights from researchers Junshang Ge, Yi Meng, Jiayue Guo, and colleagues, as they unveil a significant negative link between HPV-encoded circular RNA, circE7, and CD8+ T cell infiltration in head and neck squamous cell carcinoma. Their innovative findings suggest combining anti-PD-1 and anti-TIM-3 inhibitors could represent a novel immunotherapy approach.

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Playback language: English
Abstract
This study reveals a negative association between Human Papillomavirus (HPV)-encoded circular RNA, circE7, and CD8+ T cell infiltration in head and neck squamous cell carcinoma (HNSCC). circE7 suppresses T cell function by downregulating LGALS9 (encoding galectin-9), which interacts with TIM-3 and PD-1. The mechanism involves circE7 binding to ACC1, promoting its dephosphorylation and reducing H3K27 acetylation at the LGALS9 promoter. Combined anti-PD-1 and anti-TIM-3 inhibitors are proposed as a potential immunotherapy strategy.
Publisher
Nature Communications
Published On
Oct 04, 2024
Authors
Junshang Ge, Yi Meng, Jiayue Guo, Pan Chen, Jie Wang, Lei Shi, Dan Wang, Hongke Qu, Pan Wu, Chunmei Fan, Shanshan Zhang, Qianjin Liao, Ming Zhou, Bo Xiang, Fuyan Wang, Ming Tan, Zhaojian Gong, Wei Xiong, Zhaoyang Zeng
Tags
HPV
circE7
CD8+ T cells
HNSCC
immunotherapy
LGALS9
TIM-3

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