Health and Fitness

Healthy lifestyle practice correlates with decreased obesity prevalence in individuals with high polygenic risk: TMM CommCohort study

Y. Sutoh, T. Hachiya, et al.

This study reveals the powerful influence of lifestyle changes on obesity risk, particularly among individuals with a high genetic predisposition. Conducted by a team of researchers including Yoichi Sutoh and Tsuyoshi Hachiya, the findings indicate that increasing physical activity can significantly lower obesity risk, while high sodium intake may contribute to it. Discover how small changes can lead to profound impacts on health!

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Abstract

This study investigates the impact of lifestyle modifications on obesity risk in individuals with a high polygenic score (PGS) for obesity. Using data from the Tohoku Medical Megabank Community-Based Cohort (TMM CommCohort), the researchers found that increased leisure-time physical activity was significantly associated with reduced obesity risk across all genetic risk categories. Conversely, higher sodium intake showed a positive association with obesity risk. These results suggest that healthy lifestyle choices can mitigate obesity risk even in those with a high genetic predisposition.

Publisher

Journal of Human Genetics

Published On

Aug 22, 2024

Authors

Yoichi Sutoh, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Makoto Sasaki, Atsushi Shimizu

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