This study investigates the impact of lifestyle modifications on obesity risk in individuals with a high polygenic score (PGS) for obesity. Using data from the Tohoku Medical Megabank Community-Based Cohort (TMM CommCohort), the researchers found that increased leisure-time physical activity was significantly associated with reduced obesity risk across all genetic risk categories. Conversely, higher sodium intake showed a positive association with obesity risk. These results suggest that healthy lifestyle choices can mitigate obesity risk even in those with a high genetic predisposition.
