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Harnessing synthetic biology for advancing RNA therapeutics and vaccine design

Biology

Harnessing synthetic biology for advancing RNA therapeutics and vaccine design

B. A. Pfeifer, M. Beitelshees, et al.

Discover how Blaine A Pfeifer, Marie Beitelshees, Andrew Hill, Justin Bassett, and Charles H Jones are revolutionizing RNA-based treatments and vaccines through synthetic biology. This exciting research tackles crucial challenges, enhancing immunogenicity and mRNA lifespan for next-generation therapeutics.

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Playback language: English
Abstract
This review explores the application of synthetic biology principles to enhance RNA-based treatments and vaccines. Synthetic biology offers tools to optimize various aspects of RNA therapeutics, including the antigen, construct, activity, and delivery vector. The authors discuss how synthetic biology can address challenges in RNA technology, such as immunogenicity and mRNA lifespan, and highlight its potential in developing next-generation vaccines and therapeutics.
Publisher
npj Systems Biology and Applications
Published On
Nov 15, 2023
Authors
Blaine A Pfeifer, Marie Beitelshees, Andrew Hill, Justin Bassett, Charles H Jones
Tags
synthetic biology
RNA therapeutics
vaccines
immunogenicity
mRNA lifespan
RNA technology
therapeutics

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