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Abstract
This research demonstrates an 11-step synthesis of (±)-Licarin B, utilizing individual metal atoms and ultrasmall clusters as catalysts for key reactions. Pd atoms catalyze aerobic alcohol oxidation, Cu<sub>2-7</sub> clusters catalyze carbon-oxygen cross-couplings, Pd<sub>3-4</sub> clusters catalyze Sonogashira coupling, and Pt<sub>3-5</sub> clusters catalyze Markovnikov hydrosylilation. The synthesis also features a selective alkene hydrogenation with NaBH<sub>4</sub> and an acid-catalyzed intermolecular carbonyl-olefin metathesis. These findings highlight the potential of metal atoms and clusters in complex organic synthesis.
Publisher
Communications Chemistry
Published On
Apr 04, 2024
Authors
Silvia Rodríguez-Nuévalos, Miguel Espinosa, Antonio Leyva-Pérez
Tags
Licarin B
metal catalysts
organic synthesis
Pd atoms
Cu clusters
Sonogashira coupling
hydrosylilation

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