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GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

Medicine and Health

GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

X. Chen, X. Chen, et al.

Discover how GV-971, an anti-Alzheimer's drug, offers unexpected protection against severe acute pancreatitis in male mice. This innovative research, conducted by esteemed authors from the Affiliated Cancer Hospital & Institute of Guangzhou Medical University, reveals a fascinating interplay between gut microbiota and the immune system, modulated by key metabolites. Learn how targeting this axis could pave the way for new therapies!

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Playback language: English
Abstract
This study demonstrates that GV-971 (sodium oligomannate), an anti-Alzheimer's drug, protects against severe acute pancreatitis (SAP) in male mice. GV-971 reshapes the gut microbiota, increasing *Faecalibacterium* populations and modulating the immune system. Metabolomics analysis reveals short-chain fatty acids (SCFAs), such as propionate and butyrate, as key metabolites inhibiting lethal inflammation by blocking the MAPK pathway. These findings suggest GV-971 as a promising therapeutic for SAP by targeting the microbiota-metabolic-immune axis.
Publisher
Nature Communications
Published On
Sep 27, 2024
Authors
Xi Chen, Xin Chen, Ding Yan, Na Zhang, Wen Fu, Meixuan Wu, Feifei Ge, Jiangtuan Wang, Xiaofen Li, Meiyu Geng, Jinheng Wang, Daolin Tang, Jinbao Liu
Tags
GV-971
acute pancreatitis
gut microbiota
immune modulation
short-chain fatty acids
MAPK pathway
therapeutic potential

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