GV-971 prevents severe acute pancreatitis by remodeling the

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Abstract

This study demonstrates that GV-971 (sodium oligomannate), an anti-Alzheimer's drug, protects against severe acute pancreatitis (SAP) in male mice. GV-971 reshapes the gut microbiota, increasing *Faecalibacterium* populations and modulating the immune system. Metabolomics analysis reveals short-chain fatty acids (SCFAs), such as propionate and butyrate, as key metabolites inhibiting lethal inflammation by blocking the MAPK pathway. These findings suggest GV-971 as a promising therapeutic for SAP by targeting the microbiota-metabolic-immune axis.

Publisher

Nature Communications

Published On

Sep 27, 2024

Authors

Xi Chen, Xin Chen, Ding Yan, Na Zhang, Wen Fu, Meixuan Wu, Feifei Ge, Jiangtuan Wang, Xiaofen Li, Meiyu Geng, Jinheng Wang, Daolin Tang, Jinbao Liu

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