Medicine and Health

GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

X. Chen, X. Chen, et al.

Discover how GV-971, an anti-Alzheimer's drug, offers unexpected protection against severe acute pancreatitis in male mice. This innovative research, conducted by esteemed authors from the Affiliated Cancer Hospital & Institute of Guangzhou Medical University, reveals a fascinating interplay between gut microbiota and the immune system, modulated by key metabolites. Learn how targeting this axis could pave the way for new therapies!

00:00

Playback language: English

Index

Abstract

This study demonstrates that GV-971 (sodium oligomannate), an anti-Alzheimer's drug, protects against severe acute pancreatitis (SAP) in male mice. GV-971 reshapes the gut microbiota, increasing *Faecalibacterium* populations and modulating the immune system. Metabolomics analysis reveals short-chain fatty acids (SCFAs), such as propionate and butyrate, as key metabolites inhibiting lethal inflammation by blocking the MAPK pathway. These findings suggest GV-971 as a promising therapeutic for SAP by targeting the microbiota-metabolic-immune axis.

Publisher

Nature Communications

Published On

Sep 27, 2024

Authors

Xi Chen, Xin Chen, Ding Yan, Na Zhang, Wen Fu, Meixuan Wu, Feifei Ge, Jiangtuan Wang, Xiaofen Li, Meiyu Geng, Jinheng Wang, Daolin Tang, Jinbao Liu

Related Publications

Explore these studies to deepen your understanding of the subject.

Food Science and Technology

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice

S. Panyod, W. Wu, et al.

Medicine and Health

Omega-3 polyunsaturated fatty acids ameliorate PM2.5 exposure induced lung injury in mice through remodeling the gut microbiota and modulating the lung metabolism

J. Li, Y. Chen, et al.

Biology

The Gut Microbiota-Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool

M. Sánchez-tapia, A. Mimenza-alvarado, et al.

Biology

Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue

O. Agranyomi, S. Meininger-mordechaï, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny