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Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice

Food Science and Technology

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice

S. Panyod, W. Wu, et al.

Discover how ginger essential oil (GEO) could be a game-changer in preventing non-alcoholic steatohepatitis (NASH) as revealed by a remarkable study conducted by Suraphan Panyod and colleagues. GEO has shown potential to reduce inflammation, improve antioxidant levels, and enhance gut microbiota balance in a murine model, suggesting significant implications for dietary supplementation against NASH.

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Playback language: English
Abstract
This study investigated the protective effects of ginger essential oil (GEO) against palm oil-containing high-fat diets (HFDs) in a murine non-alcoholic steatohepatitis (NASH) model. GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; increased antioxidant levels; alleviated hepatic inflammation through the NLRP3 inflammasome and LPS/TLR4 signaling pathways; and increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance. GEO prevents NASH progression, likely by altering gut microbiota and inhibiting the LPS/TLR4/NF-κB pathway, suggesting potential as a dietary supplement for NASH prevention.
Publisher
Nutrition and Diabetes
Published On
Aug 16, 2024
Authors
Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu, Lee-Yan Sheen
Tags
ginger essential oil
non-alcoholic steatohepatitis
high-fat diets
gut microbiota
inflammation
antioxidants

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