This study investigated the protective effects of ginger essential oil (GEO) against palm oil-containing high-fat diets (HFDs) in a murine non-alcoholic steatohepatitis (NASH) model. GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; increased antioxidant levels; alleviated hepatic inflammation through the NLRP3 inflammasome and LPS/TLR4 signaling pathways; and increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance. GEO prevents NASH progression, likely by altering gut microbiota and inhibiting the LPS/TLR4/NF-κB pathway, suggesting potential as a dietary supplement for NASH prevention.
