Psychology

Gaze behaviors during free viewing revealed differences in visual salience processing across four major psychiatric disorders: a mega-analysis study of 1012 individuals

K. Miura, M. Yoshida, et al.

This groundbreaking study by Kenichiro Miura and colleagues uncovers significant visual salience processing differences among major psychiatric disorders, revealing schizophrenia patients' heightened sensitivity to low-level image features compared to healthy controls. With insights into gaze behavior, this research paves the way for understanding psychosis severity across disorders.

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Abstract

This mega-analysis study (1012 participants) investigated visual salience processing differences across four major psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder) using gaze behavior during free viewing. Schizophrenia patients showed higher salience at their gaze than healthy controls, indicating greater guidance by low-level image salience (orientation and color salience affected). A general linear model revealed a significant disease effect, with schizophrenia showing the most affected salience, followed by bipolar disorder, major depressive disorder, and autism spectrum disorder—an order consistent with psychosis severity.

Publisher

Molecular Psychiatry

Published On

Oct 11, 2024

Authors

Kenichiro Miura, Masatoshi Yoshida, Kentaro Morita, Michiko Fujimoto, Yuka Yasuda, Hideanga Yamamori, Junichi Takahashi, Seiko Miyata, Kosuke Okazaki, Junya Matsumoto, Atsuo Toyomaki, Manabu Makino, Naoki Hashimoto, Toshiaki Onitsuka, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto

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