Hippocampal formation (HF) volume loss is a well-established finding in schizophrenia. This study investigated potential associations between aerobic fitness and HF subfield structure, functional connectivity, and related cognitive impact. Significant positive associations between aerobic fitness levels and volumes were demonstrated for most HF subfields, with the strongest associations for the cornu ammonis, dentate gyrus, and subiculum. No significant associations were found for HF functional connectivity or mediation effects on verbal memory. Aerobic fitness may mitigate HF volume loss, especially in the subfields most affected in schizophrenia. This finding should be further investigated in longitudinal studies.
Publisher
Translational Psychiatry
Published On
Sep 16, 2022
Authors
Isabel Maurus, Lukas Roell, Daniel Keeser, Boris Papazov, Irina Papazova, Moritz Lembeck, Astrid Roeh, Elias Wagner, Dusan Hirjak, Berend Malchow, Birgit Ertl-Wagner, Sophia Stoecklein, Alkomiet Hasan, Andrea Schmitt, Andreas Meyer-Lindenberg, Peter Falkai
Tags
schizophrenia
aerobic fitness
hippocampal formation
volume loss
functional connectivity
cognitive impact
HF subfields
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