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Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder

Psychology

Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder

H. Hori, H. Fukushima, et al.

This groundbreaking study reveals the intricate connection between cAMP signaling and PTSD reexperiencing symptoms. Researchers demonstrate that enhanced cAMP signaling contributes to fear memory retrieval and persistence, linking lower PDE4B mRNA levels with severe reexperiencing symptoms in both PTSD patients and mice. Conducted by an expert team including Hiroaki Hori and colleagues, these insights could pave the way for new treatments in PTSD.

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Playback language: English
Abstract
This study investigates the link between cAMP signaling and PTSD reexperiencing symptoms. Using mice and human transcriptome analysis, the researchers demonstrate that facilitated cAMP signaling enhances fear memory retrieval and maintenance. Reduced PDE4B mRNA expression, which degrades cAMP, was observed in PTSD patients with severe reexperiencing symptoms and in mouse hippocampi after fear memory retrieval. Correlation between more severe reexperiencing symptoms and lower PDE4B mRNA levels was linked to decreased PDE4B DNA methylation. These findings suggest that cAMP signaling, through PDE4B downregulation, plays a key role in PTSD reexperiencing.
Publisher
Molecular Psychiatry
Published On
Feb 27, 2024
Authors
Hiroaki Hori, Hotaka Fukushima, Taikai Nagayoshi, Rie Ishikawa, Min Zhuo, Fuyuko Yoshida, Hiroshi Kunugi, Kenichi Okamoto, Yoshiharu Kim, Satoshi Kida
Tags
cAMP signaling
PTSD
PDE4B
fear memory
mRNA expression
reexperiencing symptoms

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