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Fast and light-efficient remote focusing for volumetric voltage imaging

Biology

Fast and light-efficient remote focusing for volumetric voltage imaging

U. L. Böhm and B. Judkewitz

Discover a breakthrough in biomedical research with flipped image remote focusing (FLIRF), a novel method developed by Urs L. Böhm and Benjamin Judkewitz that enhances light efficiency, paving the way for 500 volumes per second in volumetric voltage imaging. This innovative technique captured the activity of over 100 neurons in a zebrafish spinal cord, revolutionizing the potential for high-speed imaging.

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Playback language: English
Abstract
Voltage imaging, while promising for biomedical research, is limited by the need for high-speed, volume-imaging capabilities. Current remote focusing techniques are either too slow or light-inefficient. This paper introduces flipped image remote focusing (FLIRF), a method doubling light efficiency compared to conventional techniques, enabling volumetric voltage imaging at 500 volumes/s. The method's potential is demonstrated by recording activity from over 100 neurons in a zebrafish spinal cord using light sheet imaging.
Publisher
Nature Communications
Published On
Nov 05, 2024
Authors
Urs L. Böhm, Benjamin Judkewitz
Tags
voltage imaging
biomedical research
remote focusing
light efficiency
neuronal activity
zebrafish
light sheet imaging

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