Medicine and Health

Extreme transport of light in spheroids of tumor cells

D. Pierangeli, G. Perini, et al.

This groundbreaking research by Davide Pierangeli and colleagues unveils the intriguing phenomenon of optical rogue waves in tumor-cell spheroids. Utilizing randomly modulated laser beams, they reveal localized optical modes that could revolutionize light-activated therapies by delivering concentrated optical power deep within tissue.

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Abstract

This research explores the phenomenon of optical rogue waves (RWs) in tumor-cell spheroids. Using randomly modulated laser beams, the study discovered that these spheroids exhibit RWs, characterized by spatially localized optical modes with enhanced transmission. The intensity of transmitted light follows a Weibull distribution, indicating nonlinear effects responsible for the RW formation. These findings suggest potential applications in biomedical fields, particularly light-activated therapies, by enabling the concentration of significant optical power within deep tissues.

Publisher

Nature Communications

Published On

Aug 03, 2023

Authors

Davide Pierangeli, Giordano Perini, Valentina Palmieri, Ivana Grecco, Ginevra Friggeri, Marco De Spirito, Massimiliano Papi, Eugenio DelRe, Claudio Conti

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