Medicine and HealthNature Communications
Exploring protein hotspots by optimized fragment pharmacophores
D. Bajusz, W. S. Wade, et al.
Discover how a team led by Dávid Bajusz and colleagues has harnessed fragment-based drug design to create a pilot library, SpotXplorer0, that successfully identifies hits for challenging targets like SETD2 and SARS-CoV-2. This innovative approach integrates pharmacophores with protein hotspot theory, paving the way for future drug development.
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