This study investigated the efficacy of phage therapy in clearing pan-resistant Pseudomonas aeruginosa infections in vivo. A phage cocktail demonstrated strong therapeutic potential, clearing infections from the lung, kidneys, and spleen. Resistance developed in the liver due to limited phage adsorption, but this resistance surprisingly led to re-sensitization to various antibiotics. Phage steering, using the cocktail to re-sensitize bacteria, effectively cleared infections from all organs.
Publisher
Nature Communications
Published On
Feb 20, 2024
Authors
Eleri A. Ashworth, Rosanna C. T. Wright, Rebecca K. Shears, Janet K. L. Wong, Akram Hassan, James P. J. Hall, Aras Kadioglu, Joanne L. Fothergill
Tags
phage therapy
Pseudomonas aeruginosa
pan-resistant infections
antibiotics
in vivo study
therapeutic potential
phage steering
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