Biology

Experimental evidence for cancer resistance in a bat species

R. Hua, Y. Ma, et al.

This groundbreaking study explores the intriguing cancer resistance in various bat species, particularly highlighting *Myotis pilosus*, which displayed remarkable resilience against cancer. Researchers Rong Hua, Yuan-Shuo Ma, Lu Yang, and others from the Kunming Institute of Zoology have uncovered the genetic underpinnings that potentially explain this resistance, offering valuable insights into natural mechanisms of cancer resistance in mammals.

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Abstract

Mammals exhibit varying cancer rates, with longer-lived species often displaying greater resistance. While bats, known for their longevity, have been hypothesized to be cancer-resistant, this hasn't been systematically investigated. This study examines cancer resistance across seven bat species by activating oncogenic genes in their primary cells. Both in vitro and in vivo experiments suggest *Myotis pilosus* (MPI) exhibits exceptional cancer resistance. Transcriptomic and functional analyses reveal that downregulation of *HIF1A*, *COPSS*, and *RPS3* significantly contributes to this resistance. The loss of a potential enhancer containing the *HIF1A* binding site upstream of *COPSS* in MPI is identified, explaining the *COPSS* downregulation. These findings offer direct experimental evidence for cancer resistance in a bat species and provide insights into natural cancer resistance mechanisms in mammals.

Publisher

Nature Communications

Published On

Feb 15, 2024

Authors

Rong Hua, Yuan-Shuo Ma, Lu Yang, Jun-Jun Hao, Qin-Yang Hua, Lu-Ye Shi, Xiao-Qing Yao, Hao-Yu Zhi, Zhen Liu

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