Biology

Enhancing bioreactor arrays for automated measurements and reactive control with ReacSight

F. Bertaux, S. Sosa-carrillo, et al.

Discover ReacSight, a revolutionary system that enhances small-scale bioreactor arrays, offering real-time control over vital microbial processes! This innovative research by François Bertaux, Sebastián Sosa-Carrillo, Viktoriia Gross, Achille Fraisse, Chetan Aditya, Mariela Furstenheim, and Gregory Batt demonstrates state-of-the-art techniques for optogenetic control, competition assays, and dynamic culturing. Join us to explore the future of microbial research!

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Abstract

Small-scale, low-cost bioreactors offer precise control over microbial cultures' environmental parameters. This research introduces ReacSight, a system enhancing bioreactor arrays for automated measurements and reactive control. ReacSight uses low-cost pipetting robots for sample handling and integrates a flexible instrument control architecture. Its capabilities are demonstrated through three yeast applications: real-time optogenetic gene expression control, nutrient scarcity impact analysis using competition assays, and dynamic control of a two-strain consortium. ReacSight's versatility is further shown by enhancing plate readers with pipetting for antibiotic treatment studies on bacterial isolates.

Publisher

Nature Communications

Published On

Jun 11, 2022

Authors

François Bertaux, Sebastián Sosa-Carrillo, Viktoriia Gross, Achille Fraisse, Chetan Aditya, Mariela Furstenheim, Gregory Batt

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