BiologyTrends in Cell Biology
Emerging approaches to enhance human brain organoid physiology
A. Pagliaro, B. Artegiani, et al.
This review surveys cutting-edge strategies to boost the physiological relevance of brain organoids—stem cell optimization, refined morphogen delivery, ECM niche tuning, tissue-architecture engineering, co-cultures, assembloids, and in vivo xenotransplantation—offering a roadmap for more life-like models. Research conducted by Anna Pagliaro, Benedetta Artegiani, and Delilah Hendriks.
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