PsychologyNature Communications
Distributed neural representations of conditioned threat in the human brain
Z. Wen, E. F. Pace-schott, et al.
Combining fMRI from 1,465 participants across diverse threat conditioning and negative affect paradigms, this work uses multivariate pattern analysis to establish sensitive, specific, and reproducible distributed neural decoders that distinguish threat from safety and reveal dynamic shifts among neural nodes. Research was conducted by Zhenfu Wen, Edward F. Pace-Schott, Sara W. Lazar, Jörgen Rosén, Fredrik Åhs, Elizabeth A. Phelps, Joseph E. LeDoux, and Mohammed R. Milad.
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