Medicine and HealthNature

Distinguishing features of long COVID identified through immune profiling

J. Klein, J. Wood, et al.

This groundbreaking study explored the distinct biological characteristics of long COVID, revealing significant immune differences and identifying potential biomarkers for future research, conducted by an esteemed team of researchers including Jon Klein and Akiko Iwasaki.... show more

General Summary Metrics

Abstract

Post-acute infection syndromes can follow viral illnesses. SARS-CoV-2 infection may lead to long COVID, characterized by fatigue, post-exertional malaise, and cognitive/autonomic dysfunctions. The biological processes driving these symptoms are unclear. In a cross-sectional study of 275 individuals with or without long COVID, multidimensional immune phenotyping and unbiased machine learning identified biological features associated with long COVID. Participants with long COVID showed marked differences in circulating myeloid and lymphocyte populations and exaggerated humoral responses to SARS-CoV-2. Elevated antibody responses to non-SARS-CoV-2 viruses, particularly Epstein–Barr virus, were observed. Levels of soluble immune mediators and hormones varied, with lower cortisol among long COVID participants. Integration of immune data into machine learning models identified key features most strongly associated with long COVID status, providing direction for future pathobiology studies and biomarker development.

Publisher

Nature

Published On

Sep 25, 2023

Authors

Jon Klein, Jamie Wood, Jillian R. Jaycox, Rahul M. Dhodapkar, Peiwen Lu, Jeff R. Gehlhausen, Alexandra Tabachnikova, Kerrie Greene, Laura Tabacof, Amyn A. Malik, Valter Silva Monteiro, Julio Silva, Kathy Kamath, Minlu Zhang, Abhilash Dhal, Isabel M. Ott, Gabrielee Valle, Mario Peña-Hernández, Tianyang Mao, Bornali Bhattacharjee, Takehiro Takahashi, Carolina Lucas, Eric Song, Dayna McCarthy, Erica Breyman, Jenna Tosto-Mancuso, Yile Dai, Emily Perotti, Koray Akduman, Tiffany J. Tzeng, Lan Xu, Anna C. Geraghty, Michelle Monje, Inci Yildirim, John Shon, Ruslan Medzhitov, Denyse Lutchmansingh, Jennifer D. Possick, Naftali Kaminski, Saad B. Omer, Harlan M. Krumholz, Leying Guan, Charles S. Dela Cruz, David van Dijk, Aaron M. Ring, David Putrino, Akiko Iwasaki

DOI

https://doi.org/10.1038/s41586-023-06651-y

Explore these studies to deepen your understanding

Adjacent work that informs or extends this paper's methodology and findings.

Medicine and Health

Non-human primate model of long-COVID identifies immune associates of hyperglycemia

C. S. Palmer, C. Perdios, et al.

Medicine and Health

The implication of the illness metaphors of *In America*: Mitigating negative effects of metaphors through illness narratives in the postpandemic era of COVID-19

R. Dai and S. Peng

Health and Fitness

Questioning global health in the times of COVID-19: Re-imagining primary health care through the lens of politics of knowledge

R. Priya, A. Sarkar, et al.

Medicine and Health

Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

C. Sun, Y. Kang, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 22+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny