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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity

Medicine and Health

Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity

K. Arai, M. Okumura, et al.

Discover the groundbreaking findings on Seleno-insulin, an innovative artificial insulin analog developed by Kenta Arai and colleagues. This study reveals its remarkable resistance to insulin-degrading enzymes and effective hypoglycemic effects in diabetic rats, providing a fresh approach to long-acting insulin formulations.... show more
Citation Metrics
Citations
22
Influential Citations
0
Reference Count
65
Citation by Year

Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

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