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Abstract
This paper investigates sulfonamide-tethered isatin derivatives as potential anticancer agents and VEGFR-2 inhibitors. The synthesis, characterization, and in vitro biological evaluation of these compounds are described. Cytotoxicity against T47D cells was assessed using the SRB colorimetric technique. VEGFR-2 inhibition was also evaluated. Molecular dynamics simulations were performed to study the interactions between the compounds and the VEGFR-2 receptor.
Publisher
Journal of Medicinal Chemistry (Hypothetical)
Published On
Oct 26, 2024
Authors
Moataz A Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F Khaleel, Abdelrahman I Zain-Alabdeen, Zainab M Elsayed, Eslam B Elkaeed, Rofaida Salem, Claudiu T Supuran, Wagdy M Eldehna, Haytham O Tawfik
Tags
sulfonamide
isatin derivatives
anticancer agents
VEGFR-2 inhibitors
cytotoxicity
molecular dynamics
T47D cells

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