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Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

Medicine and Health

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

M. A. Shaldam, H. Almahli, et al.

Discover the potential of sulfonamide-tethered isatin derivatives as promising anticancer agents and VEGFR-2 inhibitors. This research, conducted by a team of experts, explores the synthesis, characterization, and biological evaluation of these compounds, including their cytotoxic effects on T47D cells and interactions with the VEGFR-2 receptor.

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~3 min • Beginner • English
Abstract
Publisher
Journal of Medicinal Chemistry (Hypothetical)
Published On
Oct 26, 2024
Authors
Moataz A Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F Khaleel, Abdelrahman I Zain-Alabdeen, Zainab M Elsayed, Eslam B Elkaeed, Rofaida Salem, Claudiu T Supuran, Wagdy M Eldehna, Haytham O Tawfik
Tags
sulfonamide
isatin derivatives
anticancer agents
VEGFR-2 inhibitors
cytotoxicity
molecular dynamics
T47D cells

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