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Abstract
This study aimed to discover broadly neutralizing antibodies against SARS-CoV-2 variants, especially Omicron. Using single-cell sequencing of B cells from Omicron breakthrough infection patients, they identified potent antibodies with low nanogram-per-milliliter NT50 values. Cryo-EM studies revealed structural mechanisms of broad neutralization. Rationally designed antibody cocktails demonstrated excellent neutralizing activity against all tested VOCs, including BQ.1.1 and XBB, offering a promising therapeutic candidate.
Publisher
Nature Communications
Published On
Jun 15, 2023
Authors
Yu Guo, Guangshun Zhang, Qi Yang, Xiaowei Xie, Yang Lu, Xuelian Cheng, Hui Wang, Jingxi Tang, Jielin Tang, Yuxin Gao, Hang Shang, Jun Dai, Yongka Shi, Jiazhi Zhou, Jun Zhou, Hangtian Guo, Haitao Yang, Jianwei Qi, Lijun Liu, Shihui Ma, Biao Zhang, Qianyu Huo, Yi Xie, Junpings Wu, Fang Dong, Song Zhang, Zhiyong Lou, Yan Gao, Zidan Song, Wenming Wang, Zixian Sun, Xiaoming Yang, Dongsheng Xiong, Fengjiang Liu, Xinwen Chen, Ping Zhu, Ximo Wang, Tao Cheng, Zine Rao
Tags
broadly neutralizing antibodies
SARS-CoV-2 variants
Omicron
antibody cocktails
cryogenic electron microscopy
therapeutic candidate
single-cell sequencing

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