Medicine and Health

Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study

S. Ariff, A. Aamir, et al.

This prospective observational study explores the relationship between fat-free mass and fat mass growth during the first 1000 days of life and its impact on neurodevelopment in infants from Karachi, Pakistan. Remarkably, infants with motor delays showed lower fat-free mass, while those with behavioral issues exhibited higher fat percentage, underscoring the crucial balance needed in nutritional strategies. This research was conducted by Shabina Ariff, Almas Aamir, Aneurin Young, Laila Sikanderali, Arjumand Rizvi, Fariha Shaheen, Gul Nawaz Khan, Sajid Soofi, and Michelle Fernandes.

00:00

Playback language: English

Index

Abstract

This prospective observational study examined associations between fat-free mass (FFM) and fat mass (FM) accretion during the first 1000 days of life and neurodevelopment in term-born, low-risk infants from Karachi, Pakistan. Using the deuterium dilution method to estimate BCIs and the INTER-NDA at 24 months (n=132), results showed that children with gross motor delays had significantly lower FFM at 18 months, while those with behavior problems had significantly higher fat% at 24 months. However, these associations were not significant after adjusting for covariates. Trajectory modeling indicated a critical period between 12 and 18 months where fat accretion influenced negative behavior scores. The findings highlight the need to balance neurodevelopment and metabolic risk in nutritional interventions.

Publisher

European Journal of Clinical Nutrition

Published On

Jul 12, 2023

Authors

Shabina Ariff, Almas Aamir, Aneurin Young, Laila Sikanderali, Arjumand Rizvi, Fariha Shaheen, Gul Nawaz Khan, Sajid Soofi, Michelle Fernandes

Related Publications

Explore these studies to deepen your understanding of the subject.

Health and Fitness

Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study

N. Jankovic, S. Schmitting, et al.

Medicine and Health

Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women

A. Liu, E. T. Akimova, et al.

Medicine and Health

Associations of body composition and physical fitness with gestational diabetes and cardiovascular health in pregnancy: Results from the HealthyMoms trial

P. Henriksson, J. Sandborg, et al.

Psychology

Do perceived control and time orientation mediate the effect of early life adversity on reproductive behaviour and health status? Insights from the European Value Study and the European Social Survey

B. C. Farkas, V. Chambon, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny