Detection of pyridine derivatives by SABRE hyperpolarization at zero field

This work investigates the detection of pyridine derivatives using zero-field nuclear magnetic resonance (NMR) spectroscopy enhanced by Signal Amplification by Reversible Exchange (SABRE) hyperpolarization. The authors demonstrate the unique identification of pyridine derivatives based on their zero-field NMR spectra, even when the same substituent is at different positions on the ring or different substituents are at the same position. A custom-built nitrogen vapor condenser system enables long-term measurements crucial for detecting naturally abundant hyperpolarized molecules at 1 mM concentration. This approach paves the way for future chemical detection using zero-field NMR.

Piotr Put, Seyma Alcicek, Oksana Bondar, Łukasz Bodek, Simon Duckett, Szymon Pustelny