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Abstract
This study investigated the relationship between the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) scores and cerebrospinal fluid (CSF) biomarkers in patients with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (MCI). 179 patients underwent neuropsychological assessment, LASSI-L, and CSF biomarker analysis (Aβ1-42/Aβ1-40 and ptau181). LASSI-L scores, particularly those reflecting recovery from semantic interference and delayed recall, were significantly associated with CSF biomarkers. A logistic regression model incorporating LASSI-L scores and age achieved 74.9% accuracy in detecting abnormal amyloid deposition. The study supports the biological validity of LASSI-L in detecting early Alzheimer's disease.
Publisher
Frontiers in Psychology
Published On
Authors
Maria Valles-Salgado, María José Gil-Moreno, Rosie E. Curiel Cid, Alfonso Delgado-Álvarez, Isabel Ortega-Madueño, Cristina Delgado-Alonso, Marta Palacios-Sarmiento, Juan I. López-Carbonero, María Cruz Cárdenas, Jorge Matías-Guiu, María Díez-Cirarda, David A. Loewenstein, Jordi A. Matias-Guiu
Tags
Semantic Interference
Cerebrospinal Fluid
Cognitive Decline
Alzheimer's Disease
LASSI-L
Biomarkers
Mild Cognitive Impairment

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