Chemistry

Design and directed evolution of noncanonical β-stereoselective metalloglycosidases

W. J. Jeong and W. J. Song

This groundbreaking research by Woo Jae Jeong and Woon Ju Song reveals the design of artificial metalloglycosidases—enzymes that harness metal ions for glycosidic bond hydrolysis, a rare trait in nature. Their work introduces Zn-dependent glycosidases with remarkable β-stereoselectivity and catalytic efficiency, redefining metalloenzyme design and paving the way for innovative whole-cell biocatalysts.... show more

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