Medicine and Health

Creation of a biological sensorimotor interface for bionic reconstruction

C. Festin, J. Ortmayr, et al.

Explore the cutting-edge research by Christopher Festin and colleagues, as they unveil an innovative biological interface that merges mixed nerve transfer with glabrous dermal skin transplantation in rats, offering crucial insights into the restoration of sensory feedback for neuroprosthetics.

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Playback language: English

Index

Abstract

Neuromuscular control of bionic arms has constantly improved, but sensation restoration remains elusive. This study establishes an experimental biological sensorimotor interface by transferring a mixed nerve to a skeletal muscle combined with glabrous dermal skin transplantation in a rat model. Morphological analyses reveal reinnervation of skin, mechanoreceptors, NMJs, and muscle spindles, and electrophysiological recordings show reproducible afferent signals upon tactile stimulation and tendon manipulation. This interface may allow decoding of efferent motor control and encoding of afferent tactile and proprioceptive feedback, suggesting a potential clinical translation for neuroprosthetic applications.

Publisher

Nature Communications

Published On

Jun 24, 2024

Authors

Christopher Festin, Joachim Ortmayr, Udo Maierhofer, Vlad Tereshenko, Roland Blumer, Martin Schmoll, Génova Carrero-Rojas, Matthias Luft, Gregor Laengle, Dario Farina, Konstantin D. Bergmeister, Oskar C. Aszmann

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