Medicine and Health

COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders

M. A. Moni, P. Lin, et al.

Discover the intriguing connections between COVID-19 and psychiatric disorders in this enlightening study by Mohammad Ali Moni, Ping-l Lin, Julian M. W. Quinn, and Valsamma Eapen. The research uncovers shared gene expression pathways and genomic alterations, particularly highlighting the alarming correlation between PTSD and COVID-19, alongside potential therapeutic insights in anti-inflammatory treatments.

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Playback language: English

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Abstract

Psychiatric symptoms are observed in some COVID-19 patients, but the interaction between SARS-CoV-2 infection and underlying psychiatric vulnerabilities remains unclear. This study investigated shared gene expression pathways and genomic alterations between COVID-19 and three psychiatric disorders: bipolar disorder, PTSD, and schizophrenia. Analyses of transcriptome data from peripheral blood mononuclear cells (PBMCs) and genome-wide association study (GWAS) data revealed overlapping signaling pathways and gene clusters. PTSD profiles showed the strongest correlation with COVID-19, potentially due to stress-immune system interactions. Common inflammatory pathways were also identified, suggesting potential benefits of anti-inflammatory medications. The study highlights the clinical application of multi-level datasets in treating psychiatric disorders during the COVID-19 pandemic.

Publisher

Translational Psychiatry

Published On

Authors

Mohammad Ali Moni, Ping-l Lin, Julian M. W. Quinn, Valsamma Eapen

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