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Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide

Chemistry

Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide

S. Learte-aymamí, P. Martin-malpartida, et al.

This exciting research showcases a bis-histidine peptide derived from the αH helix of the cofactor SOS1, which achieves high-affinity binding to KRAS when paired with Pd(II). The reversible binding turns it into a switchable KRAS binder, inhibiting the MAPK kinase cascade effectively. This is a breakthrough by the authors, highlighting the peptide's potential in cellular applications.... show more
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