Medicine and Health

Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma

A. Medina, N. Puig, et al.

This groundbreaking study conducted by Alejandro Medina and colleagues reveals the critical role of minimal residual disease (MRD) detection in predicting outcomes for multiple myeloma patients. Using advanced NGS and NGF technologies, the research uncovers significant correlations and highlights the stark difference in survival rates for MRD-negative patients three months post-transplantation. Discover the importance of MRD monitoring in transforming patient care.

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Playback language: English

Index

Abstract

This study evaluated minimal residual disease (MRD) 3 months post-transplantation in 106 multiple myeloma patients using next-generation sequencing (NGS, LymphoTrack®) and next-generation flow (NGF, EuroFlow). NGS had limitations due to sample processing, but showed high correlation with NGF (R² = 0.905). Three-year progression-free survival (PFS) and overall survival (OS) were significantly better for MRD-negative patients by both methods. Cox regression showed similar prognostic value for NGS and NGF negativity in predicting PFS and OS. The findings highlight the importance of MRD detection in predicting myeloma patient outcomes.

Publisher

Blood Cancer Journal

Published On

Oct 30, 2020

Authors

Alejandro Medina, Noemi Puig, Juan Flores-Montero, Cristina Jimenez, M. Eugenia Sarasquete, Maria Garcia-Alvarez, Isabel Prieto-Conde, Carmen Chillon, Miguel Alcocer, Norma C. Gutierrez, Albert Oriol, Laura Rosinol, Joan Blade, Mercedes Gironella, Miguel T. Hernandez, Veronica Gonzalez-Calle, Maria-Teresa Cederna, Bruno Paiva, Jesus F. San-Miguel, Juan-Jose Lahuerta, Maria-Victoria Mateos, Joaquin Martinez-Lopez, Alberto Orfao, Marcos Gonzalez, Ramon Garcia-Sanz

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