This study investigated the association between atopic eczema and various health outcomes using UK primary care data (1997-2023). 71 cohort studies (age, sex, general practice-matched) compared 3.6 million people with eczema to 16.8 million without. Eczema showed strong associations with atopic and allergic conditions, skin infections, Hodgkin's lymphoma, alopecia areata, Crohn's disease, urticaria, autoimmune liver disease, and irritable bowel syndrome. Sensitivity analyses explored the impact of consultation bias and cohort age. Severe eczema showed stronger associations with liver, gastrointestinal, cardiovascular conditions, osteoporosis, and fractures. Most cancers and neurological conditions were not associated with eczema.
Publisher
Nature Communications
Published On
Nov 06, 2024
Authors
Julian Matthewwan, Anna Schultze, Helen Strongman, Krishnan Bhaskaran, Amanda Roberts, Spiros Denaxas, Kathryn E Mansfield, Sinéad M Langan
Tags
atopic eczema
health outcomes
primary care data
skin infections
autoimmune diseases
cohort studies
Hodgkin's lymphoma
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