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Abstract
This study evaluated the immunogenicity, safety, and efficacy of a chimpanzee adenovirus (ChAd)-based RSV vaccine candidate, ChAd155-RSV, in a bovine RSV (bRSV) challenge model. The vaccine elicited robust neutralizing antibody responses in seronegative calves. Two doses protected calves from clinical symptoms and lung pathology, reducing virus loads after short and long intervals between immunization and challenge. Even a single dose provided significant protection. Pre-existing bRSV antibodies did not affect the two-dose regimen's efficacy. The results support further development of ChAd155-RSV as a potential RSV vaccine for infants.
Publisher
Nature Communications
Published On
Oct 17, 2022
Authors
Rineke de Jong, Norbert Stockhofe-Zurwieden, Judith Bonsing, Kai-Fen Wang, Sarah Vandepaer, Badiaa Bouzya, Jean-François Toussaint, Ilse Dieussaert, Haifeng Song, Ann-Muriel Steff
Tags
immunogenicity
safety
efficacy
RSV vaccine
calves
virus protection

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