Cervical cancer screening using DNA methylation triage in a | ResearchBunny

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Abstract

This study evaluated the WID-qCIN test, a DNA methylation triage technique, in a real-world cohort of 28,017 women aged ≥30 years undergoing cervical cancer screening. The combination of WID-qCIN and HPV16/18 detection showed high sensitivity in identifying cervical intraepithelial neoplasia grade 3 and invasive CCs. Compared to cytology, this combination predicted a significantly higher percentage of incident CIN2+ cases, suggesting improved triage efficiency.

Publisher

Nature Medicine

Published On

Jun 04, 2024

Authors

Lena Schreiberhuber, James E. Barrett, Jiangrong Wang, Elisa Redl, Chiara Herzog, Charlotte D. Vavourakis, Karin Sundström, Joakim Dillner, Martin Widschwendter

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